Many expected youngster Miquel to start at leftback with Koscielny moving to right, however Laurent Koscielny and Per Mertesacker will continue at the heart of defence, with Thomas Vermaelen in once more at left-back.
Frimpong as expected will fill in for the suspended Alex Song at the heart of midfield. Aaron Ramsey and Mikel Arteta will continue in central midfield.
Wenger has kept faith once more with the same trio in attack, as Theo Walcott, Gervinho and Robin van Persie all start in the West Midlands.
Team in full: Szczesny, Coquelin, Mertesacker, Koscielny, Vermaelen, Frimpong, Arteta, Ramsey, Walcott, Gervinho, Van Persie.
Subs: Almunia, Squillaci, Benayoun, Arshavin, Rosicky, Oxlade-Chamberlain, Chamakh.